Denver runs its own sales tax office — it is not just a rate on top of Colorado's
In most states, a city's share of sales tax is one more line the state collects, audits and remits on the city's behalf. Colorado works differently. Colorado is a "home-rule" state, meaning municipalities with a home-rule charter can choose to administer and collect their own local sales and use tax rather than have the Colorado Department of Revenue do it for them. Denver made that choice decades ago and is a "self-collected" home-rule city, one of roughly 70 in Colorado according to the Department of Revenue's own local government sales tax guidance.
What that means for a business is concrete, not academic. Registering with the Colorado Department of Revenue for a state sales tax license does not register you with Denver. The City and County of Denver's Treasury Division requires its own business tax registration, issued through the Denver eBiz Tax Center, its own two-year sales tax license, and its own return filed and paid through the Denver eBiz Tax Portal — a system the city's own tax guide confirms does not participate in the state's Sales and Use Tax System (SUTS) or the Department of Revenue's filing system at all. A Denver business effectively carries two sales tax relationships in parallel: one with the state for the 2.9% state and RTD/SCFD district shares, and one with the city treasury for Denver's own 5.15%.
Where this actually bites a business
The practical failure mode is a business that assumes a Colorado sales tax registration covers Denver, discovers it does not during an audit or a lease renewal that requires a business license, and owes back filings plus penalties to the city on top of whatever it already paid the state. It is also a common point of confusion for a business relocating into Denver from a state-collected Colorado city or from another state entirely, since almost nowhere else works this way. If you are opening a Denver location and already file Colorado sales tax elsewhere in the state, treat the Denver registration as a separate task, not a formality.